Publication highlights :
June 2007: Prof. Olivier Michielin - Proteins
The major determinant of T cell activation is the affinity of the TCR for the peptide-MHC complex. The design of optimized TCR sequence requires, therefore, the computation of the binding free energy component ...more
April 2007: Dr. Nathalie Rufer - J Immunol.
In humans, the pathways of memory and effector T-cell differentiation remain poorly defined. In the present study, we uncovered additional heterogeneity among the effector-memory (EM) subset by studying ...more
April 2007: Prof. Gerhard Christofori - Am J Pathol.
While the formation of new blood vessels (angiogenesis) during tumor growth has been a focus of cancer research for the last two decades, the functional contribution of the formation of new lymphatic vessels ...more
March 2007: Dr. Friedrich Beermann - Dev. Biol.
The key pigmentation gene tyrosinase is expressed in two different cell lineages, namely neural crest-derived melanocytes and the retinal pigment epithelium (RPE) which is derived from the optic cup. The ...more
March 2007: Prof. Curzio Rüegg - Oncogene
Tumor necrosis factor (TNF) is a pro-inflammatory cytokine exerting pleiotropic effects on endothelial cells. Depending on the vascular context, it can induce endothelial cell activation and survival or ...more
December 2006: Prof. Ivan Stamenkovic - PLoS ONE
This study has focused on the gene expression profile analysis of the stromal response to tumor invasion in a mouse model of multistep carcinogenesis of the prostate. Numerous genes that are implicated ...more
October 2006: Prof. Felix Naef - Bioinformatics
One promise of cancer systems biology is that mathematical modeling of gene networks with major roles in cellular transformations will ultimately contribute to a better understanding of the causing molecular ...more
October 2006: Dr. Friedrich Beermann - Dev Biol.
Regulation of the pigmentation gene Tyrp1 which is expressed in melanocytes and melanoma is dependent on regulatory elements in the promoter. The new experiments now show that a novel distal regulatory ...more
September 2006: Dr. Nathalie Rufer - J Immunol.
Ectopic expression of the catalytic subunit of telomerase (hTERT) results in the extension of the replicative life span of human CD8+ T lymphocytes. However, it is yet unknown whether somatic cells that ...more
July 2006: Dr. Nathalie Rufer - J Immunol.
Despite major progress in T lymphocyte analysis in melanoma patients, T-cell receptor repertoire selection and kinetics in response to tumor antigens remain largely unexplored. In this study, using a novel ...more